Screening, Diagnosing, and Monitoring Breast Cancer
Focusing on the NO.1 Disease Affecting Women’s Health
Non-invasive: No radiation, no side effect, and no pain
-One out of ten women will suffer from breast cancer in her life.
-In developed countries, 1/3 of woman cancer patients are breast
-In China, breast cancer is a dramatically growing disease, and is
the No.1disease in urban women population.
-Early detection is a critical step for disease treatment and for
improving women's life quality.
-OPTIMUS system is developed on the basis of an innovative
technology protected by several US and Chinese patents.
-OPTIMUS is the result of a combined research and development
effort by the University of Connecticut and MDT since 1998.
-This effort has been supported by a variety of resources including
the Connecticut Innovative Fund, NIH grants, Hartford Hospital, and
the Health Center of the University of Connecticut.
-As an innovative technology, it has been shown in the media like
Laser World Magazine, Radiology Magazine,and featured in television
programs on CBS.
Angiogenesis: A common denominator in breast cancer
Abnormal blood supply: An important factor in early diagnosis
Common characteristics of malignant tumor growth: Research has shown solid breast tumors become clinically relevant
once they develop a blood supply, and malignant tumors have higher
MVD of their surrounding tissues. Subtle vascular changes are often
associated with breast cancer in its earliest stages. DOT
technology can detect abnormal blood supply changes in local
tissues, and thus provide information for early diagnosis before
the detection of morphological changes.
OPTIMUS imaging: provides functional information of breast tissues, and reveals the
concentration of Hemoglobin and Oxygen saturation, reflecting
angiogenic status of lesions.
Diffusion Optical Tomography (DOT):
-Tumor Angiogenesis: In 1994, the Angiogenesis Foundation
identified angiogenesis as the “common denominator” in important
diseases, including breast cancer. Research has shown that solid
breast tumors become clinically relevant once they develop a blood
supply. Subtle vascular changes are often associated with breast
cancer in its earliest stages. Recent technology detects vascular
changes and forms a vascular profile to indicate the early vascular
-Detection with Multi-Wavelength – OPTIMUS employs multi-wavelength
DOT scan to measure HBO2 AND Deoxy HB and calculate hemoglobin
concentration and tumor hypoxia
-Probe Design – With unique NIR probes for functional imaging
design, OPTIMUS images reflect optical diffusion status in
different tissue positions
Dual Modality Imaging:
-OPTIMUS combines the advantages of ultrasound imaging and DOT
imaging to provide diagnostic information on breast lesions
-Ultrasound imaging demonstrates structural changes and anatomy of
breast tissues, allowing doctors to analyze a multiplicity of
conditions and assess lesions
-OPTIMUS imaging provides functional information on breast tissues,
and reveals the concentration of hemoglobin and oxygen saturation,
which are directly related to angiogenesis of lesion
-Ultrasound Imaging – Uses the probe in the same way as a regular.
ultrasound imaging to locate lesion or areas of interest, and
acquire an image
-Laser Scan – Uses multi-wavelength laser scan to acquire optical
information of any suspicious area
-DOT Image Construction – Reconstructs 3D functional images to
reflect the spatial distribution of HBT, HBO2, and HB
-Quantitative Analysis – Performs quantitative analysis of DOT and
ultrasound images to generate a report with BI-Rads rating
-Localization- Uses ultrasound imaging to localize tumors, which
offers good spatial resolution, and can detect breast lesions of a
few millimeters in size. OPTIMUS takes advantage of this technology
to localize tumors.
-Identification- Optical tomography is used to indicate the
likelihood of tumor malignancy, a new technique that employs
diffused light in the near infrared spectrum, provides functional
images of tumor angiogenesis and tumor hypoxia. OPTIMUS utilizes
such functional information to indicate the likelihood of tumor
-Early Detection- OPTIMUS can detect and diagnose lesions as small
as 0.5cm in diameter.
-Non-invasive- OPTIMUS performs breast imaging with
non-compression, non-radiation, and non-invasive.
-Dual modality operation and visualization, simple and easy to use
-Rich information about tumor blood and morphological
characteristics, including hemoglobin(HBT), Oxygen
concentration(SO2), tumor shape, lobe, and orientation, etc.
-CAD provides standard results in compliance with BI-RADs
-Easy and clear report generation, storage, and PACs compatible
Initial Clinical Trial in US:
HB Index Chart (8 early stage breast cancer, 57 benign tumor)
Clear Efficacy Indication
-The result shows significantly higher HB index values in the
malignant group (avg.122µmol/L)than those in the beginning group
-When a threshold of 95 is used to separate malignant and benign
lesions, the sensitivity specificity values are 100% and 96%.
-Optical tomography provides higher sensitivity and higher
specificity than color doppler ultrasound.
Clinical Trial and Data in China:
HB Index Chart
Clinical trials were performed in four hospitals in China. The
diagnosis result of OPTIMUS system was compared with X-ray
mammography and biopsy results. With 90 trial cases, OPTIMUS system
demonstrates 100% sensitivity and 86% specificity.
Screening and Diagnosis
OPTIMUS is used in a hospital specializing in tumor as a screening
and a patient diagnosis device. Among 833 women examined over a
two-month period, 38 were diagnosed as suspicious malignant
lesions. 23 out of the 38 patients underwent surgery with 20
confirmed cancer cases.
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